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NIR Inspection

Near-Infrared Spectroscopy for Controlled Release Tablets

Confirming the integrity of an osmotic drug delivery system has been simplified with the addition of NIR spectroscopy to Ackley’s line of pharmaceutical tablet laser drilling machines.

The osmotic drug delivery system is an advanced timed release mechanism usually in the form of a bi-layer tablet with a semi-permeable outer membrane which retains its integrity until it reaches the intestines. If this coating is damaged, the drug might release immediately after ingestion, which could be very harmful, or even fatal, to the consumer.

NIR Inspection provides a quick and accurate way to verify that a tablet’s enteric coating is acceptable and therefore safe for consumption. Near-infrared spectroscopy provides a unique advantage for pharmaceutical manufacturers due to its ease of use and fast, accurate analysis of solid dosage forms. This analytical technique uses the near-infrared region of the electromagnetic spectrum to provide a material signature that can be plotted to show peaks at specific wavelengths of light. This analysis provides information on a material’s composition and can provide important information about the safety and quality of coatings on OROS tablets.

Ackley’s CO2 precision laser drilling machinery is now equipped with optional near-infrared spectroscopy in addition to vision inspection. Our Class 1 Laser tablet drilling machines drill sub-millimeter sized apertures into the enteric coating of single and bi-layer tablets to achieve the desired dissolution rate and drug release profile. This fully-integrated NIR inspection system provides and increased level of safety for consumers and additional peace of mind for pharmaceutical manufacturers by giving them twice the inspection power, ensuring that only the best products make it to market.

Whatever your laser drilling needs, our engineering team is ready to design a solution that will give your controlled release product a perfectly aligned, precisely drilled aperture, each and every time.

  • NIR Inspection Osmotic Drug Delivery System Tablet Spill
  • Laser Drilling with NIR & Vision Inspection for Osmotic Drug Delivery System
  • Ackley VIP Laser Drilling Machine with Near Infrared Inspection
  • Ackley Tablet Samples 07
  • Ackley Laser Drilling Tablet Samples 03
  • Ackley Tablet Samples 08
  • Ackley Laser Drilling Tablet Samples 01

How an Osmotic Drug Delivery System Works

How Osmotic Drug Delivery Works Infographic

Did You Know?

Ackley uses the same NIR Spectrometers used by NASA in their mission to find water on the Moon.

Ackley Machine Corporation is at the forefront of cutting-edge pharmaceutical equipment manufacturing. Our VIP Laser Drill + NIR features two fully-integrated Brimrose AOTF-NIR Spectrometers, delivering fast-responding analysis of a tablet’s enteric coating. This process ensures the integrity of each osmotic controlled release pharmaceutical product prior to laser drilling. This innovative use of near-infrared technology improves OROS production quality and consistency. (Photo courtesy of Brimrose)


NIR Inspection Resources

Pharmaceutical Laser Drilling with NIR Inspection Whitepaper Cover

Pharmaceutical Laser Drilling with NIR Inspection

From sugar coatings to film and gel coatings, many types of outer coatings make tablets easier to swallow and protect from light and moisture infiltration. However, osmotic-controlled release oral delivery ...
Get the Whitepaper
VIP Laser Drill + NIR Machine

Ask an Expert: Near-infrared Inspection Systems

Learn what a near-infrared inspection (NIR) system is, how it works and what its benefits are for the pharmaceutical manufacturing industry ...
Read the Article

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